gallic acid antioxidant

The total phenolic content ranged from 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic acid equivalents. Second, under the oxidation conditions applied, it was observed that the hydrophilic and/or lipophilic character affects drastically the antioxidant activity of gallic acid derivatives. Biochem Biophys Rep. 2020 Jun 9;23:100772. doi: 10.1016/j.bbrep.2020.100772. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. This may take some time to load. Gallic Acid A potent antioxidant also found in black tea and red wine, shown in tests to inhibit cell proliferation and cell death in prostrate cancer cells. Gallic acid derivatives have also been found in a number of phytomedicines with diverse biological and pharmacological activities, including radical scavenging, interfering with the cell signaling pathways and apoptosis of cancer cells. Biol Pharm Bull. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Gallic acid is a water soluble phenolic acid present in grapes and in the leaves of many plants. The Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. USA.gov. However, we consider the latter explanation to be unlikely on account of the lack of antioxidant activity of gallic acid at the relevant concentration (1 μM) in any of the antioxidant … antioxidants Article Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin Marília Medeiros Fernandes-Negreiros 1, Lucas Alighieri Neves Costa Batista 1, Rony Lucas Silva Viana 1, Diego Araujo Sabry 1, Almino Afonso Oliveira Paiva 2, Weslley Souza Paiva 1, Raynara Iusk Araujo Machado 1, Francimar Lopes de Sousa Junior 3, If you are the author of this article you do not need to formally request permission 2020 Dec;58(1):590-596. doi: 10.1080/13880209.2020.1777169. Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti‑inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. Determination of the reducing power. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer. Gallic acid … *  |  P53 and cancer Every cell in our body has a gene called TP53 which produces a protein called p53. Please enable it to take advantage of the complete set of features! Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis. 2013;36(8):1341-7. doi: 10.1248/bpb.b13-00276. The anti-peroxide activity in the bulk oil system decreased in the order of methyl gallate>gallic acid>α-tocopherol. J Ethnopharmacol. Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling. Gallic acid (A), chlorogenic acid (B), protocatechuic acid (C) and vanillic acid (D). Deoxyribose assay. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). formally request permission using Copyright Clearance Center. HHS Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. Gallic acid (A) had the highest antioxidant capacity with 61% RSA, followed by protocatechuic acid (B), 35% RSA; chlorogenic acid (C), 28% RSA and vanillic acid had the lowest value of 11% RSA. article provided that the correct acknowledgement is given with the reproduced material. Gallic acid with the lowest hydrophobicity (log P=-0.28) was found to be the most active antiradical agent (IC50=29.5 μM), followed by methyl gallate (IC50=38.0 μM, log P=-0.23) and α-tocopherol (IC50=105.3 μM, log P=0.70). Esters of gallic acid have a diverse range of industrial uses, as antioxidants in food, in cosmetics, and in the pharmaceutical industry. Gallic acid (3,4,5-trihydroxy benzoic acid; GA) is a natural phenolic compound with low toxicity and is produced by dierent plants. Instructions for using Copyright Clearance Center page for details. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2012 Mar 1;108:16-22. doi: 10.1016/j.jphotobiol.2011.12.004. The Pseudophase Model Interpretation of the “Cutoff Effect”. Piceatannol inhibits melanogenesis by its antioxidative actions. It is a white solid, although samples are typically brown owing to partial oxidation. Corresponding authors, a Gallic acid is a trihydroxybenzoic acid found in many plants as either the free acid or in the esterified form of gallotannins and ellagitannins. Ethyl acetate extract from Panax ginseng C.A. The diverse range of applications of this simple polyphenol is due to a fine amalgam between its antioxidant and prooxidant potential. Epub 2013 Jun 4. Starting from the bioavailability and the biosynthetic pathway of gallic acid, this review includes various in vitro, in vivo and in silico studies providing the mode of action, radical scavenging activity, ability to inhibit lipid peroxidation, maintenance of endogenous defense systems and metal ion chelation by this triphenolic molecule, along with a comprehensive overview of factors responsible for its high antioxidant activity. contained in this article in third party publications This compound has antioxidant properties (an antioxidant is a substance that protects the body’s cells from the harmful free radicals) and helps to protect our cells against oxidative damage. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. eCollection 2020 Sep. Kim DE, Chang BY, Ham SO, Kim YC, Kim SY. or in a thesis or dissertation provided that the correct acknowledgement is given 2.4. Gallic acid can also be used as a starting material in the synthesis of the psychedelic alkaloid mescaline. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. catechin and quercetin, also led to the synthesis of dextran molecules with antioxidant activity. gallic acid—it could equally infer that gallic acid or delphini-din offers direct antioxidant protection resulting in protec-tion of GSH. Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a strong antioxidant and an efficient apoptosis inducing agent. Maxima in Antioxidant Distributions and Efficiencies with Increasing Hydrophobicity of Gallic Acid and Its Alkyl Esters. E-mail: However, as with other cases, us… In this present work, I attempted to investigate the effect of 200452(2), pp 255–260. Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, Nouri A. Pharm Biol. it in a third party non-RSC publication you must In all cases the Ref. eCollection 2020. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication Gallic acid (GA), that is, 3,4,5-trihydroxybenzoic acid, is a naturally occurring polyphenol commonly found in a variety of fruits and vegetables such as grapes, green tea, tea leaves or tomatoes [ This site needs JavaScript to work properly. Epub 2017 Jul 8. 2007 Jun;30(6):1135-9. doi: 10.1248/bpb.30.1135. to access the full features of the site or access our, Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India, Chemistry for Medicine: Special Collection for RSC Advances, Instructions for using Copyright Clearance Center page. It is important to recognise that the observed association between protection by GA and protection of GSH cannot in itself establish that an increase in intracellular GSH is responsible for the protective effects of gallic acid—it could equally infer that gallic acid or delphinidin offers direct antioxidant protection resulting in protection of GSH. Gallic acid acts as an antioxidant and helps to protect human cells against oxidative damage. with the reproduced material. If you are not the author of this article and you wish to reproduce material from Please enable JavaScript Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. J Biol Chem. Int J Nanomedicine. Go to our Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a … This is followed by an account of their potential clinical and industrial applications. Tel: +91-1127666313. J-STAGE, Japan Science and Technology Information Aggregator, Electronic. They can cause significant damage to parts of cells such as DNA, proteins, an… A push‐pull effect is always necessary, and ester or amide bonds seem well adapted to increase the antioxidant efficiency. Gallic acid h as been reported t o exert both pro-oxidant and antioxidant activities [13]. NLM Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice. You do not have JavaScript enabled. Gallic acid is a very important common antioxidant tea formulation, known as an Ayurvedic herb. is available on our Permission Requests page. Polyphenols form an important class of naturally occurring antioxidants, having innumerable biological activities such as anticancer, antifungal, antibacterial, antiviral, antiulcer and anticholesterol, to name a few. NIH Furthermore, data on murine tyrosinase activity and melanin biosynthesis revealed that GA effectively suppressed murine tyrosinase action and the amount of melanin. In particular, gallic acid, an antioxidant present in foods like tea and wine and produced by the gut microbiota, can push potentially cancerous proteins to cause tumours in the colon. Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10(-6) M). 2.1.  |  The differences in levels … Free radicals may be the result of stress, diet, alcohol, prescription medications, smoking, physical exercise, inflammation, or exposure to air pollutants and sunlight. ORAC (Oxygen Radical Absorbance Capacity) ORAC (Oxygen Radical Absorbance Capacity) values are a measure of the antioxidant activity. Gallic acid is a well-known natural antioxidant that is basically a secondary polyphenolic metabolite. In addition, numerous studies have reported that antioxidants possess antiviral activities. Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Biol Pharm Bull. Epub 2020 Sep 10. COVID-19 is an emerging, rapidly evolving situation. Journal of Agricultural and Food Chemistry 2013 , 61 (26) , 6533-6543. Results indicated that GA effectively down-regulated the RS generation and enhanced the GSH/GSSG ratio. Molecules. Gallic acid is an antioxidant which can inhibit both COX-2. Fetching data from CrossRef. Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. 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